Dr. Park studies the interplay between the way chromatin is folded inside the nucleus and the role it plays in epigenetic regulation that creates cellular memory. Abnormal epigenetic regulation causes a broad range of diseases, including cancer. Using super-resolution imaging of chromatin structure, single-cell sequencing methods, and genetic approaches, Dr. Park aims to define the functional role of higher-order 3D chromatin organization in epigenetic memory regulations at single-nucleus resolution. This work has the potential to establish new layers of epigenetic regulation and may lead to new cancer therapies.