Chemotherapy and hematopoietic stem cell transplantation (HCT) can cure otherwise deadly cancers such as leukemias and lymphomas. Unfortunately, there are many serious complications associated with these aggressive forms of therapy. A significant proportion of these complications have been associated with alterations in the microbiome - the bacteria, viruses and fungi that naturally live within and on us. Dr. Bhatt applies cutting-edge molecular, microbiology and computational biology approaches to understand how the microbiome may mediate these serious complications. In her bench-to-bedside and back research, the safety and effectiveness of live bacterial therapies (probiotics) will be explored.