Clinical Investigator
"Epigenetic drivers of resistance to novel therapies for bladder and kidney cancer"
Dana-Farber Cancer Institute
"Immune evasive circuits that define MRD progression in myelodysplastic syndrome"
The University of Texas MD Anderson Cancer Center
"The use of ivosidenib in IDH1-mutated clonal cytopenia of undetermined significance"
Washington University School of Medicine
"Targeting intrinsic immune signaling in pancreatic cancer with small molecule therapeutics"
Stanford University School of Medicine
"Pathogen sensing in fibroblasts restrains antitumor immunity in pancreatic cancer"
Stanford University
"Shared antigen and neoantigen-specific T cells in checkpoint blockade efficacy and toxicity"
University of Pennsylvania
"Targeting cancer-associated aberrant RNA to treat metastatic melanoma"
Dana-Farber Cancer Institute
"Dissecting spatial crosstalk in squamous cell carcinoma arising in organ transplant recipients"
Icahn School of Medicine at Mount Sinai
"Structure- and lineage-based classification and targeting of resistance in EGFR-mutant NSCLC"
The University of Texas MD Anderson Cancer Center
"Understanding and targeting chromatin reorganization in ATRX deficient sarcomas"
University of Pittsburgh
"Co-receptors modulating anti-tumor activity of human cytotoxic CD4+ effector cells"
University of California, San Francisco
"Dissecting and therapeutically exploiting synthetic lethality between NOTCH and TRIM28 to drive anti-tumor immunity in SCLC"
Dana-Farber Cancer Institute
"Targeting TRIM29 to reverse immune checkpoint inhibitor resistance in bladder cancer"
University of Michigan
"Defining follicular lymphoma transformation: molecular basis, detection and therapeutic vulnerabilities"
Dana-Farber Cancer Institute
"Therapeutic opportunities and biological mechanisms for protein-RNA dyssynchrony in medulloblastoma"
University of Michigan, Ann Arbor
"Defining microbiome stability and longitudinal shifts as biomarkers of tumor response to immune checkpoint inhibitors across multiple malignancies"
The Johns Hopkins University School of Medicine
"Tailored cellular engineering to overcome costimulation-driven CAR T cell dysfunction"
Washington University
"Regulatory mechanisms of the intestinal microbiome on chimeric antigen receptor T cells"
Stanford University
"Overcoming metabolic suppression of anti-tumor immunity in gastric cancer"
Memorial Sloan Kettering Cancer Center
"Epigenetic coupling of DNA methylation and chromatin structure on leukemic transformation and therapeutic response"
Columbia University
"Predicting leukemia risk from peripheral blood smears"
Dana-Farber Cancer Institute
Dale Frey Scientist
"Uncovering cellular development in cancer through precise genome editing"
Memorial Sloan Kettering Cancer Center
"Activity-dependent changes in RNA stability as a mechanism for synaptic plasticity"
Harvard Medical School
"The regulation and function of type IV pili in Acinetobacter biofilm formation"
University of Georgia
“Imaging and engineering of cellular communication in the brain and tumors”
Stanford University
“Catching transcription factors for degradation via the midnolin-proteasome pathway”
Dana-Farber Cancer Institute / Harvard Medical School
“Fundamental mechanisms that underlie human translation initiation and its dysregulation in cancer”
Fred Hutchinson Cancer Research Center
"Targeting membrane enzymes for next-generation precision medicine against cancer"
University of Texas Southwestern Medical Center
"Identifying functions of regulatory T cell subsets in intestinal inflammation and colorectal cancer"
The Salk Institute for Biological Studies
"Mechanism of DNA processing during non-homologous end joining"
Dana-Farber Cancer Institute
"Mechanisms of retrotransposon spread and regulation and their applications in gene therapy"
University of California, Berkeley
"Single-molecule dynamics of DNA repair assemblies in live cells"
University of Minnesota
“Molecular recording of tumor evolution in response to macrophage modulations”
Columbia University
Fellow
"Unraveling the cellular and molecular determinants of hematopoietic aging and regeneration in stem cell transplantation"
Boston Children's Hospital
"Systematic exploration of the organellar and cellular requirements of pigmentation"
Massachusetts General Hospital
"An atlas of fibroblast cell states in health and disease through functional genomics"
Memorial Sloan Kettering Institute for Cancer Research
"Expansion of the glueable and degradable targets of IMiD-CRBN"
Dana-Farber Cancer Institute
"Integrin a6ß4 in hemidesmosome dynamics: structural and functional insights for tissue homeostasis, organoid growth, and cancer"
Boston Children's Hospital
"Using commensal skin bacteria for potent, antigen-specific T cell therapy"
Stanford University School of Medicine
"De novo design of protease-activated anticancer proteins"
University of California, San Francisco
"Investigating molecular and cellular mechanisms of intra-tumoral heterogeneity in small-cell lung cancer"
Stanford University
"Inter-organ communication of protein homeostasis stress responses in vertebrate aging"
Stanford University
"Defining how early-life microbial encounters sculpt the B cell repertoire and shape vaccine responses"
University of California, Berkeley
"Mechanisms and consequences of microbiota-directed immune responses"
University of California, Berkeley
"Using hyperactive dendritic cells to generate improved cancer vaccines"
Boston Children's Hospital
"In vitro reconstitution of ribosome collision dependent signaling”
The Johns Hopkins University School of Medicine
"Leveraging polyploid Xenopus to probe spindle adaptation to increases in genome size"
University of California, Berkeley
"Genetic conflicts shape protamine evolution"
Fred Hutchinson Cancer Research Center
"Uncovering signaling mechanisms in somitogenesis through high-throughput genetic screens in robust human organoids"
Harvard University
"Decoding the transcription code: de novo protein design for precise gene regulation"
University of Washington
"Understanding how ketone body metabolites influence intestinal stemness, immune responses and tumorigenesis"
Massachusetts Institute of Technology
"Integration on oncogenic signaling and nutrient sensing by mTOR in tumors"
Harvard T.H. Chan School of Public Health
"Functional analysis of post-transcriptional RNA regulation in hypoxic macrophages"
University of Colorado Boulder
"Precision therapeutics for hematologic malignancies with splicing factor mutations"
Fred Hutchinson Cancer Research Center
"Identifying fibroblast stem cells in organ maintenance, repair, and cancer"
Stanford University
"Elucidating mechanisms that reverse the detrimental effect of RAS mutations in cancer"
Memorial Sloan Kettering Cancer Center
"Engineering next-generation T cell therapies by learning from cancer mutations"
Northwestern University
"Identifying the genomic basis for Fusobacterium nucleatum’s colonization of colorectal cancers"
Dana-Farber Cancer Institute
"Examining bacteria as a source of tumor antigens"
Massachusetts Institute of Technology
"Systematic characterization of lysosomal-targeting protein degradation"
Stanford University
"Examining bacteria as a source of tumor antigens"
Massachusetts Institute of Technology
"Investigating the role of fitness and host pressure in shaping hepatitis B diversity"
The Rockefeller University
"Targeted chemical aggregation as a general strategy to overcome cancer drug resistance"
University of California, San Francisco
"Defining mechanisms by which quorum sensing and 3D morphogenesis interact in space and time to drive Vibrio cholerae pellicle maturation"
Princeton University
"Immunologic targeting of 'undruggable' TP53 hotspot mutations through T cell receptor gene therapy"
Memorial Sloan Kettering Cancer Center
"Understanding and engineering combinatorial gene regulation in mammalian cells"
California Institute of Technology
"Mechanisms of microbial modulation of cancer immunotherapy"
Duke University School of Medicine
"Elucidating the lineage relationships of thymic mimetic cells"
Harvard Medical School
"Mechanisms underlying cis-regulatory rewiring and chromatin reorganization during epithelial to mesenchymal transition"
Stanford University School of Medicine
"Synthetic intercellular signaling circuits for threat sensing and response"
California Institute of Technology
"Spatial mechanical regulation of oncogenic signaling in tumor progression and metastasis"
University of California San Francisco
"Molecular mechanisms of inflammasome activation by intraphagosomal bacteria"
Brigham and Women's Hospital
"Mechanisms of centriole number control in multiciliated cells"
The Johns Hopkins University School of Medicine
"Defining quorum-sensing signaling patterns and their effects on gene expression and morphology in V. cholerae biofilms at the single-cell and community levels"
Princeton University
"Developing Tools to Mechanistically Investigate the mtDNA 'Common Deletion'"
Memorial Sloan Kettering Cancer Center
"Mechanisms of chromosome fragmentation generating chromothripsis"
Dana-Farber Cancer Institute / Harvard Medical School
"A general platform for preparation and study of 3O-sulfated sugars"
Harvard University
"Development of haptenizing chimeras for neoantigen generation"
The Broad Institute of MIT and Harvard
"Hepatic urea cycle function in NASH-induced HCC progression"
University of Pennsylvania
"Deciphering clonal competition between oncogenic mutant and normal cells and its effect on cancer initiation"
Fred Hutchinson Cancer Research Center
"Characterization of oncogenic kinase signaling by membraneless cytoplasmic protein granules"
University of California, San Francisco
"Estimating growth rates and fluxes using gene expression: Theory and applications"
Massachusetts Institute of Technology
"Discovery and characterization of bacterial immunity against RNA phages"
Massachusetts Institute of Technology
"Investigation of the role of peripheral secreted molecules on sleep and circadian rhythms"
University of Pennsylvania
"Elucidating PABPC1 sequence preferences and determining how these preferences shape gene regulation"
Whitehead Institute for Biomedical Research
"How do eukaryotic cells count cell cycles? Intrinsic regulation of quantized asexual replication cycles and commitment to sexual differentiation in the protozoan parasite Cryptosporidium parvum"
University of Pennsylvania
"Elucidating what determines the strength of bacterial transcription terminators"
Massachusetts Institute of Technology
"Molecular and structural basis of gene expression regulation by the nucleosome remodeling and deacetylase (NuRD) complex in human cancer"
Harvard Medical School
"Engineering novel CAR T cells targeting cancer glycocalyx barrier"
Massachusetts General Hospital
"Stress granule regulators and their roles in cancer progression"
University of Colorado Boulder
"Humanize CXCL13 expression in mouse to understand lymphoid neogenesis in cancer"
University of California, San Francisco
"Targeting Clostridioides difficile biofilm dynamics to combat recurrent infections"
Vanderbilt University Medical Center
"Dissecting heterogeneous cellular responses to oncogenic KRAS inhibition in pancreatic adenocarcinoma"
Memorial Sloan Kettering Cancer Center
"Elucidating the contributions of diet and exercise on the redox environment of the gut"
Stanford University School of Medicine
"Endogenous retroviruses modulation of intestinal immune homeostasis and tumor development"
National Institutes of Health
"Defining the molecular landscape and native interactome of the Siglec-sialoglycan axis in disease"
Stanford University
"Discovery and characterization of bacteriophage effectors of bacterial immune systems"
Massachusetts Institute of Technology
"Regulatory T cells in health and disease: from Foxp3 dependence to resilience and back again"
Memorial Sloan Kettering Cancer Center
"Decoding cell-cell interactions aiding angiogenesis and immune evasion in early-stage lung cancer"
Boston Children's Hospital
"Investigating bacterial small RNA-mediated regulation of host behavior"
Princeton University
"Mitochondrial ubiquitylation mechanisms to exploit metabolic vulnerabilities in cancer"
University of California, Berkeley
"Cellular structural biology of an evolutionarily-ancient organizer of cell shape and movement"
University of California, San Francisco
"Investigating neutrophil functional heterogeneity in wound healing and cancer"
University of Calgary
"Neuroimmune: cancer stem cell interactions in the tumor microenvironment"
The Rockefeller University
"Spatiotemporal regulation of eDNA release in Pseudomonas aeruginosa biofilms"
California Institute of Technology
"High-throughput precision genome editing for dissecting complex traits in yeast and human cell lines"
Stanford University School of Medicine
"Emergency myelopoiesis pathways as common drivers of clonal dominance and disease progression in acute myeloid leukemia"
Columbia University
"Mechanistic interrogation of robustness and vulnerability in a bacterial essential gene network"
Harvard Medical School
"From form to function: Cell shape, cell ordering, and gene regulation in bacterial biofilm"
Yale University / Michigan State University
"Targeted genetic supplementation by harnessing transposable elements"
University of California, Berkeley
"Engineered cellular fusogens for novel immune effector functions"
University of California, San Francisco
"Illuminating error correction strategies in early development"
University of Pennsylvania
"Investigating innate immune activation in the autoimmune pancreas"
University of Washington
"Identifying the selective mechanism behind U2AF1 mutations in lung adenocarcinoma"
Dana-Farber Cancer Institute
"Dissecting the molecular identity and contents of neuronal synapses using spatially resolved RNA sequencing"
The Broad Institute of MIT and Harvard
"Understanding CD8 T cell epigenetic changes fueled by S-adenosylmethionine metabolism for improved adoptive cell therapy"
Van Andel Institute
"Functional dissection of the bacterial-host interface during cell-to-cell spread"
Massachusetts Institute of Technology
"Modulation of neuronal circuitry using sonogenetics"
The Salk Institute for Biological Studies
"Identifying cytoplasmic nucleases that shatter micronucleated chromosomes"
University of California, San Diego
"Spatial organization and inheritance regulation of oncogenic extrachromosomal DNA (ecDNA)"
Stanford University School of Medicine
"Chemoproteomic platforms for deciphering and drugging redox regulation between methionine and methionine sulfoxide in pancreatic cancer"
Princeton University
"Microbiome-Cancer Connection: From Understanding to Rational Design with Defined Communities"
Stanford University
"Preventing tumor evasion of CAR T killing: engineering adhesion molecules to enhance cell immunotherapy"
University of California, San Francisco
"Understanding the role of R-loops in cancer at the single cell level"
Memorial Sloan Kettering Cancer Center
"Developing tools to decode endogenous protein monoaminylation"
Princeton University
"Determining how cancer cachexia influences gluconeogenesis"
Massachusetts Institute of Technology
"Decode the senescent cell surface in vivo and develop cell therapies for senescence-related diseases"
Memorial Sloan Kettering Institute for Cancer Research
"An integrated imaging- and sequencing-based spatial-omic method to study tumor evolution"
Whitehead Institute for Biomedical Research
"Drugging K-Ras(G12D) with targeted covalent inhibitors"
University of California, San Francisco
"Mapping and modeling the human CD4+ T cell differentiation gene regulatory network"
Gladstone Institutes
"Charting the tumor antigen landscape of breast cancer"
Brigham and Women's Hospital
Innovator
"Skin commensal bacteria as a novel source of systemic antitumor immunity"
The Broad Institute of MIT and Harvard
"Targeting mitochondrial transporters in cancer"
Harvard T.H. Chan School of Public Health
"Nibbled to death: improving macrophage's ability to kill solid tumors by trogocytosis"
"Tumor-macrophage metabolic symbiosis as a driver of disease progression and therapeutic resistance"
Memorial Sloan Kettering Cancer Center
"A new platform to study cancer biology and therapy in humans"
Icahn School of Medicine at Mount Sinai
"Spatially resolved cellular competition in oncogenesis"
University of Pennsylvania
"Engineered multispecific antibody-drug conjugates as novel cancer immunotherapeutics"
Johns Hopkins University
"Identifying and disrupting the bioelectric circuits driving brain cancer"
Brigham and Women's Hospital
"X marks the spot: exploring how X-chromosome alterations drive sex differences in cancer"
Dana-Farber Cancer Institute
"Unveiling the tumor antigenome through immune intelligence"
New York University School of Medicine
Physician-Scientist
"Investigating chromatin architectural dynamics mediated by LDB1 in T-cell acute lymphoblastic leukemia"
University of Pennsylvania
"Characterizing mechanisms of resistance to Menin inhibitors in KMT2A-rearranged and NPM1-mutant AML"
Dana-Farber Cancer Institute
"Understanding the role of KMT2D in MLL-AF9 acute myeloid leukemia"
The Rockefeller University
"Using liquid biopsy and MRI to non-invasively identify therapeutic targets for brain metastases"
Massachusetts General Hospital
"Elucidating the mechanisms of inflammation in clonal hematopoiesis"
Dana-Farber Cancer Institute
"Origin and evolution of long-lived CAR T cells in patients with hematologic malignancies"
Memorial Sloan Kettering Cancer Center
"Uncovering microenvironmental dependencies in follicular lymphoma"
Brigham and Women's Hospital
"Defining the mechanistic implications of SF3B1 mutations in MDS"
Dana-Farber Cancer Institute
"Elucidating the role of KAT6A and KAT6B in the epigenetic reprogramming of neuroblastoma to enforce neuronal differentiation"
Dana-Farber Cancer Institute
"Defining the mechanism of thrombosis in patients with multiple myeloma"
Dana-Farber Cancer Institute
Quantitative Biology Fellow
"A probabilistic framework for deconvolving causal mechanisms of cancer therapeutics with genetic perturbation screens"
"A computational platform for predicting whole-embryo morphologies from single-cell transcriptomes"
University of Washington
"The biophysics of substrate recognition in chromatin remodeling"
Princeton University
"Signal bottleneck theory for dissecting gene interactions in pancreatic cancer"
Dana-Farber Cancer Institute
"Exploring phase condensation as a general mechanism for organizing cell-cell communication assemblies"
University of California, San Francisco / Washington University
"Screening migratory modes and drug delivery schedules in 3D spheroids of triple-negative breast cancer cells"
Princeton University
"Microbial genome variation in hematopoietic stem-cell transplantation patients"
Stanford University School of Medicine
St. Jude
"Investigation of receptor tyrosine kinase-independent mechanisms of FGFR1-mediated oncogenesis in pediatric gliomas"
Dana-Farber Cancer Institute
"Development and evaluation of T cell receptor (TCR)-based immunotherapy to target pediatric Acute Megakaryoblastic Leukemia"
Stanford University
"Addressing antigen heterogeneity in pediatric gliomas with tumor-assimilating multispecific immune cell engagers"
"The N-Ras palmitoylation cycle as a therapeutic target in pediatric acute myeloid leukemia"
University of California, San Francisco
"Investigating the neuronal regulation of radioresistance in diffuse midline gliomas"
Dana-Farber Cancer Institute
"Investigating the role and therapeutic potential of microbiome and bile acids in immune recovery and graft-versus-host disease in pediatric allogeneic transplantation"
"Application of single-cell approaches to investigate the developmental origin and early transformation steps of osteosarcoma"
Dana-Farber Cancer Institute
"Enhancing immune synapse formation with synthetic adhesion to overcome chimeric antigen receptor-T cell resistance in pediatric B cell malignancies"
University of California, San Francisco
"Identifying mechanisms of immune evasion in a murine model of osteosarcoma"
Dana-Farber Cancer Institute
"Decoding mechanisms of B-acute lymphoblastic leukemia pathogenesis through the lens of genomics"
Dana-Farber Cancer Institute
"Functional characterization of tumor neuronal networks that drive ependymoma"
St. Jude Children's Research Hospital
CONNECT
1.877.7CANCER
info@damonrunyon.org
One Exchange Plaza
55 Broadway, Suite 302
New York, NY 10006
